Toru Hosoi Selected Research

4-phenylbutylamine

1/2012	Protective effects of 4-phenylbutyrate derivatives on the neuronal cell death and endoplasmic reticulum stress.
6/2006	Suppressive effects of 4-phenylbutyrate on the aggregation of Pael receptors and endoplasmic reticulum stress.
10/2004	Sodium 4-phenylbutyrate protects against cerebral ischemic injury.

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Toru Hosoi Research Topics

Disease

22	Obesity 01/2023 - 12/2008
12	Body Weight (Weight, Body) 11/2021 - 02/2002
8	Neuroblastoma 01/2022 - 10/2004
6	Anorexia 01/2022 - 02/2002
5	Alzheimer Disease (Alzheimer's Disease) 01/2023 - 03/2003
5	Insulin Resistance 01/2023 - 09/2010
5	Inflammation (Inflammations) 04/2012 - 02/2002
4	Infections 02/2010 - 02/2002
3	Fever (Fevers) 01/2022 - 02/2002
3	Brain Ischemia (Cerebral Ischemia) 01/2015 - 10/2004
3	Ischemia 11/2004 - 10/2004
3	Hypoxia (Hypoxemia) 11/2004 - 10/2004
2	Disease Progression 12/2022 - 09/2004
2	Parkinson Disease (Parkinson's Disease) 01/2022 - 01/2010
2	Parkinsonian Disorders (Parkinsonism) 01/2012 - 06/2006
2	Inborn Urea Cycle Disorders 01/2012 - 10/2004
2	Infarction (Infarctions) 10/2004 - 10/2004
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2023
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2022
1	Neurodevelopmental Disorders 01/2022
1	Pheochromocytoma 01/2022
1	Mitochondrial Diseases (Mitochondrial Disease) 04/2021
1	MYD88 Deficiency 01/2021
1	Femoral Fractures (Femoral Fracture) 05/2019
1	Osteoporosis 05/2019
1	Triple Negative Breast Neoplasms 04/2019
1	AIDS-Related Complex (ARC) 01/2017
1	Diabetes Mellitus 01/2016
1	Brain Injuries (Brain Injury) 01/2015
1	Breast Neoplasms (Breast Cancer) 05/2014
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2012
1	Virus Diseases (Viral Diseases) 01/2012
1	Neoplasms (Cancer) 01/2012
1	Liver Diseases (Liver Disease) 09/2010
1	Sleep Wake Disorders 02/2010
1	Central Nervous System Diseases (CNS Diseases) 01/2010
1	Stroke (Strokes) 10/2004

Drug/Important Bio-Agent (IBA)

28	LeptinIBA 01/2023 - 02/2002
11	Hormones (Hormone)IBA 01/2023 - 01/2009
6	Leptin ReceptorsIBA 01/2022 - 11/2014
5	Fatty Acids (Saturated Fatty Acids)IBA 04/2021 - 10/2004
5	CytokinesIBA 01/2016 - 03/2003
4	Proteins (Proteins, Gene)FDA Link 12/2022 - 10/2004
4	LipopolysaccharidesIBA 01/2022 - 09/2004
4	Insulin (Novolin)FDA Link 01/2022 - 09/2010
3	Toll-Like Receptor 4IBA 01/2016 - 02/2010
3	LigandsIBA 04/2012 - 02/2010
3	4-phenylbutylamineIBA 01/2012 - 10/2004
2	Amyloid (Amyloid Fibrils)IBA 01/2023 - 12/2022
2	HomocysteineIBA 01/2022 - 01/2010
2	Glucose (Dextrose)FDA LinkGeneric 01/2017 - 05/2014
2	Telomerase (Telomerase Reverse Transcriptase)IBA 01/2016 - 05/2014
2	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 01/2016 - 02/2010
2	Endoplasmic Reticulum Chaperone BiPIBA 11/2014 - 11/2004
2	Flurbiprofen (Froben)FDA LinkGeneric 06/2014 - 01/2014
2	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 06/2014 - 01/2014
2	4-phenylbutyric acid (Buphenyl)FDA Link 01/2012 - 10/2004
2	Endothelin Receptors (Endothelin Receptor)IBA 01/2012 - 06/2006
2	InterleukinsIBA 08/2003 - 02/2002
1	alkanninIBA 01/2023
1	Phosphatidylinositols (Phosphatidylinositol)IBA 01/2022
1	ChromatinIBA 01/2022
1	Ligases (Synthetase)IBA 01/2022
1	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 01/2022
1	midnolinIBA 01/2022
1	UbiquitinIBA 01/2022
1	Transcription Factors (Transcription Factor)IBA 01/2022
1	CorticosteroneIBA 01/2021
1	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2021
1	RANK LigandIBA 05/2019
1	CalciumIBA 05/2019
1	Alkaline PhosphataseIBA 05/2019
1	MineralsIBA 05/2019
1	Tartrate-Resistant Acid PhosphataseIBA 05/2019
1	OsteocalcinIBA 05/2019
1	Insulin-Like PeptidesIBA 05/2019
1	Prednisolone (Predate)FDA LinkGeneric 05/2019
1	OsteoprotegerinIBA 05/2019
1	norwogoninIBA 04/2019
1	4-hydroxy-2-nonenal (4-hydroxynonenal)IBA 01/2019
1	PalmitatesIBA 01/2017
1	Small Interfering RNA (siRNA)IBA 01/2017
1	BIBR 1532IBA 01/2016
1	Non-Receptor Type 1 Protein Tyrosine PhosphataseIBA 01/2016
1	15-deoxyprostaglandin J2IBA 05/2015
1	EpiregulinIBA 01/2015
1	Epidermal Growth Factor (EGF)IBA 01/2015
1	AmphiregulinIBA 01/2015
1	Fluvoxamine (Luvox)FDA LinkGeneric 01/2012
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 01/2012
1	Casein Kinase II (Casein Kinase 2)IBA 01/2012
1	Selective Serotonin Reuptake Inhibitors (Serotonin Reuptake Inhibitors)IBA 01/2012
1	Toll-Like Receptors (Toll-Like Receptor)IBA 09/2010
1	CholesterolIBA 09/2010
1	CystatinsIBA 10/2005
1	interleukin 20 (IL-20)IBA 11/2004
1	Messenger RNA (mRNA)IBA 11/2004
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 10/2004
1	EdaravoneIBA 10/2004

Therapy/Procedure

1	Therapeutics 01/2015